Seasonal influenza causes thousands of deaths annually. Part of the problem is that the vaccine must be administered annually because the virus presents different immunological faces to avoid detection. Dr. Peter Palese is a pioneer in studying the molecular biology of the influenza viruses. Today he and colleagues are on a quest to identify a universal flu vaccine that would provide one-time durable immunity. We discuss the strategies and progress toward this public health milestone. # COLABRA Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/ # TALKING BIOTECH Twitter: https://twitter.com/talkingbiotech Website: https://www.colabra.app/podcasts/talking-biotech/ Instagram: https://www.instagram.com/colabrahq The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.